Epstein - Barr Virus infection induces indoleamine 2 , 3 - dioxygenase 1 expression in human monocyte - derived macrophages through 2 p 38 / MAPK and NF - κ B pathways : impairment in T cell functions
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چکیده
4 Wan-li Liu , Yue-hao Lin , Han Xiao, Shan Xing, Hao Chen, Pei-dong Chi, 5 Ge Zhang* 6 7 State Key Laboratory of Oncology in Southern China, Collaborative Innovation 8 Center of Cancer Medicine, Sun Yat-sen University Cancer Center; 9 Department of Clinic Lab, Sun Yat-sen University cancer center; 10 Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical 11 Sciences, Sun Yat-sen University , 12 Guangzhou, China 13 14 15 # Wan-li Liu and Yue-hao Lin contributed equally to this work. 16
منابع مشابه
Epstein-Barr virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-κB pathways: impairment in T cell functions.
UNLABELLED Epstein-Barr virus (EBV) infection has been observed in tumor-infiltrated macrophages, but its infection effects on macrophage immune functions are poorly understood. Here, we showed that some macrophages in the tumor stroma of nasopharyngeal carcinoma (NPC) tissue expressed the immunosuppressive protein indoleamine 2,3-dioxygenase (IDO) more strongly than did tumor cells. EBV infect...
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